The ABSORB bioresorbable vascular scaffold: A novel, fully resorbable drug-eluting stent: Current concepts and overview of clinical evidence

Catheter Cardiovasc Interv. 2015 Oct;86(4):664-77. doi: 10.1002/ccd.26172.

Abstract

The advent of fully bioresorbable stent technology and specifically the ABSORB™, a bioresorbable vascular scaffold (BVS) stent, is heralded as breakthrough technology in the current era of percutaneous coronary interventions. This article reviews the current understanding of this technology along with the clinical evidence from trials and registries of ABSORB BVS that included patients with both simple as well as more complex "real-world" coronary lesions. In addition, considering the current limitations of this device-mostly associated with the mechanical properties of the polymeric scaffold structure-a review of guidelines on successful implantation of the ABSORB BVS is presented. Although expert feedback suggests extensive use of this device in routine clinical practice outside the United States despite a paucity of data on long-term safety in this setting, attention to procedural details and implantation technique is obligatory to achieve optimal clinical outcomes.

Keywords: ABSORB BVS; bioresorbable vascular scaffold; fourth revolution; safety; stent; vascular reparative therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Absorbable Implants*
  • Angioplasty, Balloon, Coronary / methods*
  • Angioplasty, Balloon, Coronary / mortality
  • Coronary Angiography / methods
  • Coronary Artery Bypass / methods
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / mortality
  • Coronary Artery Disease / therapy*
  • Coronary Restenosis / diagnostic imaging
  • Coronary Restenosis / surgery
  • Drug-Eluting Stents*
  • Everolimus / pharmacology
  • Evidence-Based Medicine
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Prosthesis Design
  • Risk Assessment
  • Severity of Illness Index
  • Sirolimus / pharmacology
  • Survival Analysis
  • Time Factors
  • Tissue Scaffolds
  • Treatment Outcome

Substances

  • Everolimus
  • Sirolimus