Pre-eclampsia and Future Female Malignancy

Objective: To investigate an association between pre-eclampsia and future genital tract and breast malignancies.

Methods: The incidence of genital tract and breast malignancies was compared in a cohort of women with and without a history of pre-eclampsia. Cumulative incidence was assessed using a Kaplan-Meier survival curve.

Results: During the study period, 103 180 deliveries met the inclusion criteria; 8.1% occurred in patients with pre-eclampsia. Patients with pre-eclampsia did not have a significantly different risk of genital tract or breast malignancies. The results remained insignificant in a sub-analysis based on malignancy type, pre-eclampsia severity and number of episodes per patient. No difference in cumulative incidence was demonstrated.

Conclusion: Pre-eclampsia does not appear to influence the risk of future genital tract or breast malignancies.