A clinical technique utilizing autologous cultured epithelial cells in vestibule deepening operations is described. Epithelial cells from oral mucosa were grown in tissue culture on a feeder layer, released from their flasks and placed with the basal side up on the recipient beds. The cultured cells induced rapid healing of the wound, which was free of pain and contractions. The greatest advantage of this technique is that there is no size limitation on wounds that can be covered by cultured epithelial cells.