Abstract
We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter baumannii, for which Ile-B1 was most active. One combination met the criteria for synergy, B3 plus Ile-B1. No combinations exhibited antagonism. The dominant components of polymyxin B products (B1 and B2) were associated with the lowest probability of improved antibacterial activity when combined.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
MeSH terms
-
Acinetobacter baumannii / drug effects
-
Acinetobacter baumannii / growth & development
-
Anti-Bacterial Agents / pharmacology*
-
Caprylates / chemistry*
-
Drug Synergism
-
Escherichia coli / drug effects
-
Escherichia coli / growth & development
-
Klebsiella pneumoniae / drug effects
-
Klebsiella pneumoniae / growth & development
-
Microbial Sensitivity Tests
-
Polymyxin B / analogs & derivatives
-
Polymyxin B / chemistry
-
Polymyxin B / pharmacology*
-
Pseudomonas aeruginosa / drug effects
-
Pseudomonas aeruginosa / growth & development
-
Structure-Activity Relationship*
Substances
-
Anti-Bacterial Agents
-
Caprylates
-
Polymyxin B