The advancement of human pluripotent stem cell-derived therapies into the clinic

Development. 2015 Sep 15;142(18):3077-84. doi: 10.1242/dev.126482.

Abstract

Human pluripotent stem cells (hPSCs) offer many potential applications for drug screening and 'disease in a dish' assay capabilities. However, a more ambitious goal is to develop cell therapeutics using hPSCs to generate and replace somatic cells that are lost as a result of disease or injury. This Spotlight article will describe the state of progress of some of the hPSC-derived therapeutics that offer the most promise for clinical use. Lessons from developmental biology have been instrumental in identifying signaling molecules that can guide these differentiation processes in vitro, and will be described in the context of these cell therapy programs.

Keywords: Clinical medicine; HPSC-cardiomyocytes; Human Pluripotent Stem Cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation / physiology*
  • Cell- and Tissue-Based Therapy / methods*
  • Cell- and Tissue-Based Therapy / trends*
  • Diabetes Mellitus, Type 1 / therapy
  • Government Regulation
  • Heart Failure
  • Humans
  • Parkinson Disease / therapy
  • Pluripotent Stem Cells / transplantation*
  • Regenerative Medicine / methods*
  • Regenerative Medicine / trends*
  • Retinal Degeneration / therapy
  • Signal Transduction / physiology*
  • Spinal Cord Injuries / therapy