Abstract
Ribose modified 1'-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbrüggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.
Keywords:
1′-cyano pyrimidine nucleosides; HCV; Nucleosides.
MeSH terms
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Chemistry Techniques, Synthetic
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DNA-Directed RNA Polymerases / antagonists & inhibitors*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Hepacivirus / enzymology*
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Pyrimidine Nucleosides / chemical synthesis*
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Pyrimidine Nucleosides / chemistry
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Pyrimidine Nucleosides / pharmacology*
Substances
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Enzyme Inhibitors
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Pyrimidine Nucleosides
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DNA-Directed RNA Polymerases