Molecular Signature of the Ebola Virus Associated with the Fishermen Community Outbreak in Aberdeen, Sierra Leone, in February 2015

Maria R Capobianchi; Cesare E M Gruber; Fabrizio Carletti; Silvia Meschi; Concetta Castilletti; Francesco Vairo; Mirella Biava; Claudia Minosse; Gino Strada; Gina Portella; Rossella Miccio; Valeria Minardi; Luca Rolla; Abdul Kamara; Giovanni Chillemi; Alessandro Desideri; Antonino Di Caro; Giuseppe Ippolito

doi:10.1128/genomeA.01093-15

Molecular Signature of the Ebola Virus Associated with the Fishermen Community Outbreak in Aberdeen, Sierra Leone, in February 2015

Genome Announc. 2015 Sep 24;3(5):e01093-15. doi: 10.1128/genomeA.01093-15.

Authors

Maria R Capobianchi¹, Cesare E M Gruber², Fabrizio Carletti², Silvia Meschi², Concetta Castilletti², Francesco Vairo², Mirella Biava², Claudia Minosse², Gino Strada³, Gina Portella³, Rossella Miccio³, Valeria Minardi³, Luca Rolla³, Abdul Kamara⁴, Giovanni Chillemi⁵, Alessandro Desideri⁶, Antonino Di Caro², Giuseppe Ippolito²

Affiliations

¹ National Institute for Infectious Diseases "L. Spallanzani," Rome, Italy [email protected].
² National Institute for Infectious Diseases "L. Spallanzani," Rome, Italy.
³ Emergency NGO, Milan, Italy.
⁴ National Laboratory Services, Ministry of Health and Sanitation, Freetown, Sierra Leone.
⁵ CINECA, Rome, Italy.
⁶ Department of Biology, University of Rome Tor Vergata, Rome, Italy Molecular Digital Diagnostics (MDD), Viterbo, Italy.

Abstract

We report the complete genome sequence of Ebola virus from a health worker linked to a cluster of cases occurring in the fishing community of Aberdeen, Sierra Leone (February 2015), which were characterized by unusually severe presentation. The sequence, clustering in the SL subclade 3.2.4, harbors mutations potentially relevant for pathogenesis.