Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics

Samuel L Hutson; Kelsey M Wheeler; David McLone; David Frim; Richard Penn; Charles N Swisher; Peter T Heydemann; Kenneth M Boyer; A Gwendolyn Noble; Peter Rabiah; Shawn Withers; Jose G Montoya; Kristen Wroblewski; Theodore Karrison; Michael E Grigg; Rima McLeod

doi:10.1093/cid/civ720

Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics

Clin Infect Dis. 2015 Dec 15;61(12):1831-4. doi: 10.1093/cid/civ720. Epub 2015 Sep 24.

Authors

Samuel L Hutson¹, Kelsey M Wheeler¹, David McLone², David Frim³, Richard Penn⁴, Charles N Swisher², Peter T Heydemann⁵, Kenneth M Boyer⁵, A Gwendolyn Noble², Peter Rabiah⁶, Shawn Withers¹, Jose G Montoya⁷, Kristen Wroblewski⁸, Theodore Karrison⁸, Michael E Grigg⁹, Rima McLeod¹

Affiliations

¹ Department of Ophthalmology and Visual Science, The University of Chicago.
² Northwestern University and Lurie Children's Hospital and Medical Center.
³ Section of Neurosurgery, The University of Chicago.
⁴ Department of Bioengineering, College of Engineering, College of Medicine, University of Illinois at Chicago.
⁵ Department of Pediatrics, Rush University Medical Center, Chicago.
⁶ North Shore University Hospital, Evanston, Illinois.
⁷ Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, California.
⁸ Department of Public Health Sciences, The University of Chicago, Illinois.
⁹ Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland.

Abstract

Four anatomical patterns of hydrocephalus secondary to congenital Toxoplasma gondii infection were identified and characterized for infants enrolled in the National Collaborative Chicago-based Congenital Toxoplasmosis Study. Analysis of parasite serotype revealed that different anatomical patterns associate with Type-II vs Not-Exclusively Type-II strains (NE-II) (P = .035).

Keywords: Toxoplasma gondii; aqueductal obstruction; foraminal obstruction; hydrocephalus.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Genotype*
Humans
Hydrocephalus / parasitology*
Hydrocephalus / pathology*
Serogroup
Toxoplasma / classification*
Toxoplasma / genetics*
Toxoplasma / isolation & purification
Toxoplasmosis, Congenital / complications*

Abstract

Publication types

MeSH terms

Grants and funding