Failure to Validate a Multivariable Clinical Prediction Model to Identify Pediatric Intensive Care Unit Patients at High Risk for Candidemia

Brian T Fisher; Rachael K Ross; Emmanuel Roilides; Debra L Palazzi; Mark J Abzug; Jill A Hoffman; David M Berman; Priya A Prasad; A Russell Localio; William J Steinbach; Lambrini Vogiatzi; Ankhi Dutta; Theoklis E Zaoutis

doi:10.1093/jpids/piv024

Failure to Validate a Multivariable Clinical Prediction Model to Identify Pediatric Intensive Care Unit Patients at High Risk for Candidemia

J Pediatric Infect Dis Soc. 2016 Dec;5(4):458-461. doi: 10.1093/jpids/piv024. Epub 2015 Apr 29.

Authors

Brian T Fisher^{1

2

3

4}, Rachael K Ross^{1

2}, Emmanuel Roilides⁵, Debra L Palazzi⁶, Mark J Abzug⁷, Jill A Hoffman⁸, David M Berman⁹, Priya A Prasad¹⁰, A Russell Localio^{2

3

4}, William J Steinbach¹¹, Lambrini Vogiatzi¹², Ankhi Dutta⁶, Theoklis E Zaoutis^{1

2

3

4}

Affiliations

¹ Division of Infectious Diseases.
² the Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Pennsylvania.
³ Department of Pediatrics.
⁴ The Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁵ Infectious Diseases Unit, 3rd Department of Pediatrics, Aristotle University School of Health Sciences and Hippokration Hospital, Thessaloniki, Greece.
⁶ Infectious Diseases Section, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston.
⁷ University of Colorado School of Medicine and Children's Hospital Colorado, Aurora.
⁸ Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California.
⁹ All Children's Hospital, St. Petersburg, Florida.
¹⁰ Department of Epidemiology and Biostatistics, University of California San Francisco.
¹¹ Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
¹² Pediatric Intensive Care Unit, Hippokration General Hospital, Thessaloniki, Greece.

Abstract

We attempted to validate a previously derived clinical prediction rule for candidemia in the pediatric intensive care unit. This multicenter case control study did not identify significant association of candidemia with most of the previously identified predictors. Additional study in larger cohorts with other predictor variables is needed.

Keywords: ICU; candidemia; pediatric; prediction; validation.

Publication types

Multicenter Study
Validation Study

MeSH terms

Adolescent
Candidemia / diagnosis*
Case-Control Studies
Child
Child, Preschool
Decision Support Techniques*
Female
Humans
Infant
Infant, Newborn
Intensive Care Units, Pediatric*
Male

Grants and funding

R01 AI103315/AI/NIAID NIH HHS/United States