3D Printed Microtransporters: Compound Micromachines for Spatiotemporally Controlled Delivery of Therapeutic Agents

Adv Mater. 2015 Nov;27(42):6644-50. doi: 10.1002/adma.201503095. Epub 2015 Sep 28.

Abstract

Functional compound micromachines are fabricated by a design methodology using 3D direct laser writing and selective physical vapor deposition of magnetic materials. Microtransporters with a wirelessly controlled Archimedes screw pumping mechanism are engineered. Spatiotemporally controlled collection, transport, and delivery of micro particles, as well as magnetic nanohelices inside microfluidic channels are demonstrated.

Keywords: 3D printing; magnetism; micromachines; microrobotics; targeted cell delivery; targeted drug delivery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Line, Tumor
  • Drug Delivery Systems / instrumentation
  • Drug Delivery Systems / methods*
  • Equipment Design
  • Humans
  • Lab-On-A-Chip Devices
  • Magnetite Nanoparticles
  • Microtechnology / instrumentation
  • Microtechnology / methods*
  • Printing, Three-Dimensional*
  • Wireless Technology

Substances

  • Magnetite Nanoparticles