Abstract
A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. This PM-coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit development of tumor metastasis.
Keywords:
biomimetic; drug delivery; nanomedicine; nanoparticle; platelet.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology
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Biomimetic Materials / chemistry*
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Blood Platelets / cytology*
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Cell Line, Tumor
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Cell Membrane / chemistry
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Doxorubicin / chemistry
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Doxorubicin / pharmacology
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Drug Carriers / chemistry*
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Humans
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Intracellular Space / metabolism
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Mice
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Nanomedicine / methods*
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Nanostructures / chemistry*
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TNF-Related Apoptosis-Inducing Ligand / chemistry
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TNF-Related Apoptosis-Inducing Ligand / metabolism
Substances
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Antineoplastic Agents
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Drug Carriers
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TNF-Related Apoptosis-Inducing Ligand
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Doxorubicin