Abstract
Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.
MeSH terms
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Animals
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Cellular Senescence / genetics*
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Humans
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Interleukin-1alpha / genetics
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Interleukin-1alpha / metabolism
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / metabolism
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Models, Genetic
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Protein Biosynthesis*
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism
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RNA Stability
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Signal Transduction / drug effects
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Signal Transduction / genetics
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Sirolimus / pharmacology
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TOR Serine-Threonine Kinases / metabolism*
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Transcription, Genetic*
Substances
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Interleukin-1alpha
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Intracellular Signaling Peptides and Proteins
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MAP-kinase-activated kinase 2
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Protein Serine-Threonine Kinases
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TOR Serine-Threonine Kinases
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Sirolimus