Abstract
We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient. Hepatotoxicity induced by masitinib, a tyrosine kinase inhibitor, is usually transient with mild elevation of transaminases, although acute hepatitis has been not reported to date. The hepatitis was resolved after masitinib was discontinued and a combination of prednisone and azathioprine was started. The transaminases returned to baseline normal values five months later. This is the first case in the hepatitis literature associated with masitinib. The autoimmune role of this drug-induced liver injury is discussed. Physicians should be aware of this potential complication.
Keywords:
Amyotrophic lateral sclerosis; Autoimmune-like hepatitis; Autoimmunity; Drug-induced liver injury; Idiosyncratic drug hepatotoxicity; Masitinib; Tirosine kinase inhibitors.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amyotrophic Lateral Sclerosis / diagnosis
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Amyotrophic Lateral Sclerosis / drug therapy*
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Azathioprine / therapeutic use
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Benzamides
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Biopsy
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Chemical and Drug Induced Liver Injury / diagnosis
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Chemical and Drug Induced Liver Injury / drug therapy
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Chemical and Drug Induced Liver Injury / etiology*
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Drug Therapy, Combination
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Female
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Hepatitis, Autoimmune / diagnosis
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Hepatitis, Autoimmune / drug therapy
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Hepatitis, Autoimmune / etiology*
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Humans
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Immunosuppressive Agents / therapeutic use
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Piperidines
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Prednisone / therapeutic use
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Protein Kinase Inhibitors / adverse effects*
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Pyridines
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Randomized Controlled Trials as Topic
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Severity of Illness Index
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Thiazoles / adverse effects*
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Time Factors
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Treatment Outcome
Substances
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Benzamides
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Immunosuppressive Agents
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Piperidines
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Protein Kinase Inhibitors
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Pyridines
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Thiazoles
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masitinib
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Azathioprine
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Prednisone