Suspected non-AD pathology in mild cognitive impairment

Neurobiol Aging. 2015 Dec;36(12):3152-3162. doi: 10.1016/j.neurobiolaging.2015.08.029. Epub 2015 Sep 7.

Abstract

We aim to better characterize mild cognitive impairment (MCI) patients with suspected non-Alzheimer's disease (AD) pathology (SNAP) based on their longitudinal outcome, cognition, biofluid, and neuroimaging profile. MCI participants (n = 361) from ADNI-GO/2 were designated "amyloid positive" with abnormal amyloid-beta 42 levels (AMY+) and "neurodegeneration positive" (NEU+) with abnormal hippocampal volume or hypometabolism using fluorodeoxyglucose-positron emission tomography. SNAP was compared with the other MCI groups and with AMY- controls. AMY-NEU+/SNAP, 16.6%, were older than the NEU- groups but not AMY- controls. They had a lower conversion rate to AD after 24 months than AMY+NEU+ MCI participants. SNAP-MCI participants had similar amyloid-beta 42 levels, florbetapir and tau levels, but larger white matter hyperintensity volumes than AMY- controls and AMY-NEU- MCI participants. SNAP participants performed worse on all memory domains and on other cognitive domains, than AMY-NEU- participants but less so than AMY+NEU+ participants. Subthreshold levels of cerebral amyloidosis are unlikely to play a role in SNAP-MCI, but pathologies involving the hippocampus and cerebrovascular disease may underlie the neurodegeneration and cognitive impairment in this group.

Keywords: Amyloidosis; Cerebrovascular disease; Cognition; Mild cognitive impairment; Primary age-related tauopathy; Suspected non-AD pathology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / metabolism
  • Cognition
  • Cognitive Dysfunction / metabolism
  • Cognitive Dysfunction / pathology*
  • Cognitive Dysfunction / psychology
  • Female
  • Hippocampus / metabolism
  • Hippocampus / pathology
  • Humans
  • Male
  • Memory
  • Middle Aged
  • Nerve Degeneration
  • Neuroimaging
  • Peptide Fragments / metabolism

Substances

  • Amyloid beta-Peptides
  • Peptide Fragments
  • amyloid beta-protein (1-42)