Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report

J Investig Med High Impact Case Rep. 2013 Dec 17;1(4):2324709613517493. doi: 10.1177/2324709613517493. eCollection 2013 Oct-Dec.

Abstract

Glatiramer acetate (GA, Copaxone) is an approved drug for the treatment of relapsing-remitting multiple sclerosis. Most common side effects observed with GA are local injection site reactions, which can include pain, swelling, or redness. However, systemic adverse event such as hepatotoxicity related to GA is rarely seen. In this report, we present a case of GA-induced toxic hepatitis associated with cholestatic and hepatocellular damage.

Keywords: glatiramer acetate; multiple sclerosis; toxic hepatitis.