Abstract
The key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these issues, we developed gold-installed polyethyleneimine/siRNA complexes with a corona of PEGylated hyaluronic acid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Drug Carriers / chemistry
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Drug Delivery Systems*
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Gold / chemistry*
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Hyaluronic Acid / chemistry
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Metal Nanoparticles / chemistry*
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Mice
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NIH 3T3 Cells
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Neoplasms, Experimental / metabolism
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Polyethylene Glycols / chemistry
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Polyethyleneimine / chemistry
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Protein Corona / chemistry
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RNA, Small Interfering / administration & dosage*
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RNA, Small Interfering / chemistry
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RNA, Small Interfering / pharmacokinetics*
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Tissue Distribution
Substances
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Drug Carriers
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Protein Corona
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RNA, Small Interfering
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Polyethylene Glycols
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Gold
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Polyethyleneimine
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Hyaluronic Acid