Abstract
Two enantiomeric pairs of meroterpenoids, (-)- and (+)-rhodonoids A (1a and 1b) and B (2a and 2b), were isolated unprecedentedly from partially racemic mixtures that naturally occurred in Rhododendron capitatum. Their structures were fully determined by spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. Compounds 1a and 1b are the first examples of meromonoterpenes featuring a unique 6/6/6/4 ring system. Compounds 2a and 2b showed PTP1B inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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Circular Dichroism
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Crystallography, X-Ray
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
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Rhododendron / chemistry*
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Stereoisomerism
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
Substances
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Terpenes
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rhodonoid A
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rhodonoid B
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Protein Tyrosine Phosphatase, Non-Receptor Type 1