The Long, the Short, and the Unstructured: A Unifying Model of miRNA Biogenesis

Rémy Denzler; Markus Stoffel

doi:10.1016/j.molcel.2015.09.014

The Long, the Short, and the Unstructured: A Unifying Model of miRNA Biogenesis

Mol Cell. 2015 Oct 1;60(1):4-6. doi: 10.1016/j.molcel.2015.09.014.

Authors

Rémy Denzler¹, Markus Stoffel²

Affiliations

¹ Institute of Molecular Health Sciences, ETH Zurich, Otto-Stern-Weg 7, HPL H36, 8093 Zurich, Switzerland. Electronic address: [email protected].
² Institute of Molecular Health Sciences, ETH Zurich, Otto-Stern-Weg 7, HPL H36, 8093 Zurich, Switzerland. Electronic address: [email protected].

PMID: 26431024
DOI: 10.1016/j.molcel.2015.09.014

Abstract

In this issue, Fang and Bartel (2015) report the identification of novel sequence and structural features of human pri-miRNAs, which--together with previously identified sequence motifs--define a unifying model of mammalian pri-miRNAs and advances the de novo design of artificial pri-miRNAs.

Publication types

Comment

MeSH terms

Computational Biology / methods*
Humans
MicroRNAs / metabolism*
RNA Precursors / chemistry*

Substances

MicroRNAs
RNA Precursors