Abstract
Interferons are polypeptides that naturally occur in the human body as a part of the innate immune response. By harnessing these immunomodulatory functions, synthetic interferons have shown efficacy in combating various diseases including cutaneous T-cell lymphoma. This article closely examines the qualities of interferon alfa and interferon gamma and the evidence behind their use in the 2 most common types of cutaneous T-cell lymphomas, namely, mycosis fungoides and Sézary syndrome.
Keywords:
Cutaneous T-cell lymphoma; Interferon alfa; Interferon gamma; Interferons; Mycosis fungoides; Sézary syndrome.
Copyright © 2015 Elsevier Inc. All rights reserved.
MeSH terms
-
Antineoplastic Agents / therapeutic use
-
Antineoplastic Combined Chemotherapy Protocols / pharmacology
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Combined Modality Therapy / methods
-
Humans
-
Interferon-alpha / adverse effects
-
Interferon-alpha / pharmacology
-
Interferon-alpha / therapeutic use*
-
Interferon-beta / therapeutic use
-
Interferon-gamma / adverse effects
-
Interferon-gamma / pharmacology
-
Interferon-gamma / therapeutic use*
-
Mycosis Fungoides / drug therapy*
-
Mycosis Fungoides / therapy
-
PUVA Therapy / methods
-
Retinoids / therapeutic use
-
Skin Neoplasms / drug therapy*
-
Skin Neoplasms / therapy
Substances
-
Antineoplastic Agents
-
Interferon-alpha
-
Retinoids
-
Interferon-beta
-
Interferon-gamma