Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

Jordan Atchison; Sukanta Kamila; Conor McEwan; Heather Nesbitt; James Davis; Colin Fowley; Bridgeen Callan; Anthony P McHale; John F Callan

doi:10.1039/c5cc07022h

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

Chem Commun (Camb). 2015 Dec 7;51(94):16832-5. doi: 10.1039/c5cc07022h.

Authors

Jordan Atchison¹, Sukanta Kamila¹, Conor McEwan¹, Heather Nesbitt¹, James Davis², Colin Fowley¹, Bridgeen Callan¹, Anthony P McHale¹, John F Callan¹

Affiliations

¹ Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. [email protected].
² Engineering Research Institute, University of Ulster, Jordanstown, Northern Ireland BT37 0QB, UK.

PMID: 26435142
DOI: 10.1039/c5cc07022h

Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

MeSH terms

Animals
HeLa Cells
Humans
Hydrogen-Ion Concentration
Mice
Mice, SCID
Pancreatic Neoplasms / therapy*
Photochemotherapy / methods*
Photosensitizing Agents / therapeutic use*
Reactive Oxygen Species / metabolism*

Substances

Photosensitizing Agents
Reactive Oxygen Species