Early culture conversion and cure for extensively drug-resistant tuberculosis is possible with appropriate treatment: lessons learnt from a case study in South Africa

Int J Infect Dis. 2015 Nov:40:92-4. doi: 10.1016/j.ijid.2015.09.020. Epub 2015 Oct 13.

Abstract

Despite the relevance of extensively drug-resistant tuberculosis (XDR-TB) to global TB control efforts, case reports on patients achieving cure are scarce. The case of a patient who was treated for more than 3 years as a multidrug-resistant TB (MDR-TB) case, and who was diagnosed retrospectively with XDR-TB, is presented herein. Soon after the initiation of a capreomycin and para-aminosalicylic acid-based regimen, the patient converted and treatment was completed successfully.

Keywords: Culture contamination; Successful cure; XDR-TB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aminosalicylic Acid / administration & dosage
  • Aminosalicylic Acid / therapeutic use*
  • Antitubercular Agents / therapeutic use*
  • Capreomycin / administration & dosage
  • Capreomycin / therapeutic use*
  • Drug Therapy, Combination
  • Extensively Drug-Resistant Tuberculosis / drug therapy*
  • Extensively Drug-Resistant Tuberculosis / epidemiology
  • Female
  • Humans
  • Middle Aged
  • South Africa / epidemiology

Substances

  • Antitubercular Agents
  • Capreomycin
  • Aminosalicylic Acid