Abstract
Stratified scaffolds are promising devices finding application in the field of osteochondral tissue engineering. In this scaffold type, different biomaterials are chosen to fulfill specific features required to mimic the complex osteochondral tissue interface, including cartilage, interlayer tissue, and subchondral bone. Here, the biomaterials and fabrication methods currently used to manufacture stratified multilayered scaffolds as well as cell seeding techniques for their characterization are presented.
Keywords:
Alginate; Biomaterial; Mesenchymal stem cells; Osteochondral tissue engineering; Stratified scaffold.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alginates / chemistry
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Biomarkers / metabolism
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Bone Transplantation
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Cartilage / cytology*
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Cartilage / metabolism
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Cartilage / transplantation
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Cell Culture Techniques
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Cell Differentiation
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Cells, Cultured
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Chondrocytes / metabolism
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Chondrocytes / physiology*
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Chondrocytes / transplantation
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Chondrogenesis*
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Femur Head / cytology*
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Femur Head / metabolism
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Glucuronic Acid / chemistry
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Hexuronic Acids / chemistry
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Humans
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Mesenchymal Stem Cell Transplantation
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Mesenchymal Stem Cells / metabolism
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Mesenchymal Stem Cells / physiology*
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Osteogenesis*
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Phenotype
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Regeneration
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Regenerative Medicine / methods*
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Time Factors
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Tissue Engineering / methods*
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Tissue Scaffolds*
Substances
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Alginates
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Biomarkers
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Hexuronic Acids
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Glucuronic Acid