Activation of Mg(2+)-dependent DNAzymes based on AP site-containing triplex for specific melamine recognition

Ya Wang; Junying Zhang; Linling Zhu; Linlin Lu; Chongchong Feng; Fengyang Wang; Zhiai Xu; Wen Zhang

doi:10.1039/c5an01515d

Activation of Mg(2+)-dependent DNAzymes based on AP site-containing triplex for specific melamine recognition

Analyst. 2015 Nov 21;140(22):7508-12. doi: 10.1039/c5an01515d.

Authors

Ya Wang¹, Junying Zhang¹, Linling Zhu¹, Linlin Lu¹, Chongchong Feng¹, Fengyang Wang¹, Zhiai Xu¹, Wen Zhang¹

Affiliation

¹ School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P.R. China. [email protected] [email protected].

PMID: 26451392
DOI: 10.1039/c5an01515d

Abstract

Based on melamine binding-triggered triplex formation and subsequent activation of Mg(2+)-dependent DNAzymes, a novel strategy for DNAzyme regulation was proposed and developed for melamine recognition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Biosensing Techniques
Cations, Divalent / metabolism
DNA, Catalytic / chemistry
DNA, Catalytic / metabolism*
Magnesium / metabolism*
Spectrometry, Fluorescence
Triazines / analysis
Triazines / metabolism*

Substances

Cations, Divalent
DNA, Catalytic
Triazines
Magnesium
melamine