Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release

Colloids Surf B Biointerfaces. 2015 Dec 1:136:470-8. doi: 10.1016/j.colsurfb.2015.09.056. Epub 2015 Oct 1.

Abstract

Multifunctional folic acid conjugated BSA@Fe3O4 microcapsules (FA-BSA@Fe3O4 MCs) have been prepared successfully based on the sonochemical method. The as-synthesized FA-BSA@Fe3O4 MCs have a suitable size range for biomedical applications, and a high loading capacity for water-insoluble drugs. Furthermore, FA-BSA@Fe3O4 MCs show excellent magnetic properties. Cytotoxicity tests indicate that FA-BSA@Fe3O4 MCs are non-toxic. Cellular uptake and flow cytometric assay illustrate together that FA-BSA@Fe3O4 MCs can target tumor cells selectively through molecular targeted endocytosis. As carriers for water-insoluble drugs, FA-BSA@Fe3O4 MCs are also proved to possess superior redox- and thermo- dual responsiveness for controlled drug release.

Keywords: Microcapsule; Multifunctional; Release; Sonochemical; Targeted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capsules*
  • Drug Delivery Systems*
  • HeLa Cells
  • Humans
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Serum Albumin, Bovine / chemistry*

Substances

  • Capsules
  • Serum Albumin, Bovine