Abstract
On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / analogs & derivatives*
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Acyclovir / pharmacology
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology
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Cell Line
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Cytomegalovirus / drug effects
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Cytomegalovirus Infections / drug therapy
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Ganciclovir / analogs & derivatives*
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Ganciclovir / pharmacology
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Herpes Genitalis / drug therapy
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Herpes Simplex / drug therapy
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Herpesvirus 1, Human / drug effects
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Herpesvirus 2, Human / drug effects
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Humans
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Organoselenium Compounds / chemistry*
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Organoselenium Compounds / pharmacology
Substances
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Antiviral Agents
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Organoselenium Compounds
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Ganciclovir
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Acyclovir