Interferon alpha induced and maintained complete remission in chronic granulocytic leukemia in relapse after bone marrow transplantation

P Borgies; A Ferrant; A Delannoy; H Van den Berghe; J L Michaux

Interferon alpha induced and maintained complete remission in chronic granulocytic leukemia in relapse after bone marrow transplantation

Bone Marrow Transplant. 1989 Jan;4(1):127-8.

Authors

P Borgies¹, A Ferrant, A Delannoy, H Van den Berghe, J L Michaux

Affiliation

¹ Department of Haematology, Cliniques Universitaires St-Luc, Brussels, Belgium.

PMID: 2647178

Abstract

We describe a patient with chronic granulocytic leukaemia (CGL) who relapsed after allogeneic bone marrow transplantation (BMT). Interferon alpha 2b (IFN alpha 2b) induced and maintained a complete remission. IFN alpha 2b led to full restoration of donor bone marrow. This case provides evidence to support a trial of IFN alpha in patients with relapsing CGL after BMT.

Publication types

Case Reports

MeSH terms

Adult
Bone Marrow Transplantation*
Combined Modality Therapy
Graft Survival / drug effects
Hematopoiesis / drug effects
Humans
Hydroxyurea / therapeutic use
Interferon Type I / therapeutic use*
Interferon alpha-2
Interferon-alpha / therapeutic use*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / surgery*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
Male
Recombinant Proteins
Remission Induction
Transplantation, Homologous

Substances

Interferon Type I
Interferon alpha-2
Interferon-alpha
Recombinant Proteins
Hydroxyurea