The use of bone marrow cells grown in long-term culture for autologous bone marrow transplantation in acute myeloid leukaemia: an update

J Chang; G R Morgenstern; L H Coutinho; J H Scarffe; T Carr; D P Deakin; N G Testa; T M Dexter

The use of bone marrow cells grown in long-term culture for autologous bone marrow transplantation in acute myeloid leukaemia: an update

Bone Marrow Transplant. 1989 Jan;4(1):5-9.

Authors

J Chang¹, G R Morgenstern, L H Coutinho, J H Scarffe, T Carr, D P Deakin, N G Testa, T M Dexter

Affiliation

¹ Department of Experimental Haematology, Paterson Institute, Christie Hospital, Manchester, UK.

PMID: 2647188

Abstract

Eleven patients with acute myeloid leukaemia have been transplanted with autologous marrow grown in long-term bone marrow culture. In the high risk group (six patients who had all previously relapsed) the procedure induced a remission in two patients who were in florid relapse at the time of the transplant. Five patients were transplanted in first remission and they remain well and disease-free between 150 and 12 weeks after their autologous transplant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bone Marrow Transplantation*
Cells, Cultured
Combined Modality Therapy
Cytarabine / administration & dosage
Daunorubicin / administration & dosage
Humans
Leukemia, Myeloid, Acute / drug therapy
Leukemia, Myeloid, Acute / pathology
Leukemia, Myeloid, Acute / surgery*
Pilot Projects
Remission Induction
Risk
Thioguanine / administration & dosage
Transplantation, Autologous

Substances

Cytarabine
Thioguanine
Daunorubicin