Targeting leukemia's "fatty tooth"

Blood. 2015 Oct 15;126(16):1874-5. doi: 10.1182/blood-2015-08-665125.

Abstract

In this issue of Blood, Ricciardi et al report a novel fatty acid oxidation (FAO) inhibitor, ST1326, that effectively inhibits proliferation, survival, and chemoresistance in leukemia cell lines and primary samples.

Publication types

  • Comment

MeSH terms

  • Carnitine / analogs & derivatives*
  • Carnitine O-Palmitoyltransferase / antagonists & inhibitors*
  • Drug Delivery Systems*
  • Fatty Acids / metabolism*
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy*
  • Neoplasm Proteins / antagonists & inhibitors*

Substances

  • Fatty Acids
  • Neoplasm Proteins
  • Carnitine O-Palmitoyltransferase
  • Carnitine