[Atypic hemolytic uremic syndrome taken for Goodpasture's syndrome: A case report]

Marie Bourgault; Damien Sarret; Pierre Isnard; Marion Rabant; Jacques Labaye

doi:10.1016/j.nephro.2015.05.002

[Atypic hemolytic uremic syndrome taken for Goodpasture's syndrome: A case report]

Nephrol Ther. 2015 Dec;11(7):564-8. doi: 10.1016/j.nephro.2015.05.002. Epub 2015 Oct 21.

[Article in French]

Authors

Marie Bourgault¹, Damien Sarret², Pierre Isnard², Marion Rabant³, Jacques Labaye²

Affiliations

¹ Service de néphrologie, hôpital d'instruction des armées du Val-de-Grâce, 74, boulevard Port-Royal, 75005 Paris, France. Electronic address: [email protected].
² Service de néphrologie, hôpital d'instruction des armées du Val-de-Grâce, 74, boulevard Port-Royal, 75005 Paris, France.
³ Service d'anatomopathologie, hôpital Necker, 149, rue de Sèvres, 75015 Paris, France.

PMID: 26475667
DOI: 10.1016/j.nephro.2015.05.002

Abstract

We report the case of a patient suffering from atypical hemolytic uremic syndrome with inaugural intra-alveolar hemorrhage. Clinical features and detection of circulating anti-glomerular basal membrane antibodies first raise the possibility of a Goodpasture syndrome. Renal biopsy allows to correct the diagnosis. Partial remission is obtained thanks to specific care and eculizumab infusions.

Keywords: Anti-GBM antibodies; Anticorps anti-MBG; Atypical hemolytic uremic syndrome; Eculizumab; Hémorragie intra-alvéolaire; Intra-alveolar hemorrhage; Plasma exchange; Pneumo-renal syndrome; Syndrome hémolytique et urémique atypique; Syndrome pneumo-rénal; Échanges plasmatiques; Éculizumab.

Publication types

Case Reports

MeSH terms

Anti-Glomerular Basement Membrane Disease / diagnosis*
Antibodies, Monoclonal, Humanized / therapeutic use
Diagnosis, Differential
Hemolytic-Uremic Syndrome / diagnosis*
Hemorrhage / etiology
Humans
Kidney / pathology*
Lung Diseases / etiology*
Male
Middle Aged

Substances

Antibodies, Monoclonal, Humanized
eculizumab