Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens

Hanna G Budayeva; Elizabeth A Rowland; Ileana M Cristea

doi:10.1128/JVI.03220-14

Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens

J Virol. 2015 Oct 21;90(1):5-8. doi: 10.1128/JVI.03220-14. Print 2016 Jan 1.

Authors

Hanna G Budayeva¹, Elizabeth A Rowland¹, Ileana M Cristea²

Affiliations

¹ Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
² Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA [email protected].

Abstract

For a number of years, sirtuin enzymes have been appreciated as effective "sensors" of the cellular environment to rapidly transmit information to diverse cellular pathways. Much effort was placed into exploring their roles in human cancers and aging. However, a growing body of literature brings these enzymes to the spotlight in the field of virology. Here, we discuss sirtuin functions in the context of viral infection, which provide regulatory points for therapeutic intervention against pathogens.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Host-Pathogen Interactions*
Humans
Metabolic Networks and Pathways
Models, Biological
Sirtuins / metabolism*
Virus Diseases / immunology*

Substances

Sirtuins

Abstract

Publication types

MeSH terms

Substances

Grants and funding