Lymphomas are a well-known complication of therapy following organ transplantation. To date we have seen one lymphoma develop in a group of 24 patients who have undergone single or double lung transplantation. We report a 16-year-old man who developed multiple, rapidly appearing pulmonary nodules four months following transplantation. The Epstein-Barr virus and immunosuppressant drugs such as cyclosporine A have been implicated in the pathogenesis of this patient's rapidly progressive and fatal course.