Abstract
Four withanolides (1-4) and two sucrose esters (5, 6) were isolated from the aerial parts of Physalis neomexicana. The structures of 1-6 were elucidated through a variety of spectroscopic techniques. Cytotoxicity studies of the isolates revealed that 2 inhibited human breast cancer cell lines (MDA-MB-231 and MCF-7) with IC50 values of 1.7 and 6.3 μM, respectively.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Esters
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Female
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Physalis / chemistry*
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Plant Components, Aerial / chemistry*
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Sucrose / analogs & derivatives*
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Sucrose / chemistry
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Sucrose / isolation & purification*
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Sucrose / pharmacology
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Withanolides / chemistry
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Withanolides / isolation & purification*
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Withanolides / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Esters
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Withanolides
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Sucrose