Germinal center selection and the antibody response to influenza

Gabriel D Victora; Patrick C Wilson

doi:10.1016/j.cell.2015.10.004

Germinal center selection and the antibody response to influenza

Cell. 2015 Oct 22;163(3):545-8. doi: 10.1016/j.cell.2015.10.004. Epub 2015 Oct 22.

Authors

Gabriel D Victora¹, Patrick C Wilson²

Affiliations

¹ Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Electronic address: [email protected].
² Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address: [email protected].

Abstract

In this Minireview, we discuss basic aspects of germinal center biology in the context of immunity to influenza infection and speculate on how the simultaneous evolutionary races of virus and antibody may impact our efforts to design a universal influenza vaccine.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Antibody Formation
Germinal Center / immunology*
Humans
Influenza Vaccines / immunology*
Influenza, Human / immunology*
Influenza, Human / prevention & control

Substances

Influenza Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding