Abstract
Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids / chemistry
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Animals
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Coloring Agents / chemistry*
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Heating
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Hydrogen-Ion Concentration
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Light
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Liposomes / chemistry
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Mice
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Nanoparticles / chemistry*
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Photoacoustic Techniques / methods*
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Photochemical Processes*
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Rotaxanes / chemistry*
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Spectrophotometry, Ultraviolet
Substances
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Acids
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Coloring Agents
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Liposomes
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Rotaxanes