Small molecules that promote regenerative repair for pancreatic and cardiovascular health

Elnaz Menhaji-Klotz; David A Price

doi:10.1016/j.bmcl.2015.10.054

Small molecules that promote regenerative repair for pancreatic and cardiovascular health

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5465-71. doi: 10.1016/j.bmcl.2015.10.054. Epub 2015 Oct 19.

Authors

Elnaz Menhaji-Klotz¹, David A Price¹

Affiliation

¹ Worldwide Medicinal Chemistry, Pfizer, Inc., 610 Main St., Cambridge, MA 02139, United States.

PMID: 26508547
DOI: 10.1016/j.bmcl.2015.10.054

Abstract

Regenerative medicine for repair of organ injury is an emerging area of research. The use of embryonic stem cells and induced pluripotent cells in combination with endogenously expressed growth factors has provided methods to generate differentiated cells for cell-based therapy and for screening purposes. As cell-based therapies continue to be investigated in the clinical setting, small molecules for in situ tissue repair are being reported. In this review, we focus on the reports applicable to the field of cardiovascular and metabolic disease by discussing small molecules that target β-cells, cardiomyocytes and endothelial cells.

Keywords: Cardiovascular disease; Diabetes; Regenerative medicine.

Publication types

Review

MeSH terms

Cardiovascular Diseases / drug therapy
Cardiovascular System / drug effects*
Diabetes Mellitus / drug therapy
Drug Delivery Systems*
Humans
Metabolic Diseases / drug therapy
Pancreas / drug effects*
Regeneration / drug effects*
Small Molecule Libraries / pharmacology
Small Molecule Libraries / therapeutic use

Substances

Small Molecule Libraries