Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

Adv Mater. 2015 Dec 16;27(47):7816-22. doi: 10.1002/adma.201503676. Epub 2015 Oct 28.

Abstract

The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.

Keywords: biodistribution; biofabrication; cell quality control; nanoparticles; protein materials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Escherichia coli K12 / genetics
  • Models, Molecular
  • Nanostructures / chemistry
  • Nanotechnology / methods*
  • Peptides / chemistry
  • Peptides / genetics
  • Peptides / metabolism
  • Protein Engineering / methods*
  • Protein Structure, Secondary
  • Proteins / chemistry*
  • Proteins / genetics*
  • Proteins / metabolism
  • Quality Control

Substances

  • Peptides
  • Proteins