Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides

Org Biomol Chem. 2016 Jan 14;14(2):564-569. doi: 10.1039/c5ob01950h.

Abstract

A regio- and stereoselective synthesis of highly substituted α-haloenamides was described via the zinc halide mediated direct addition of benzhydryl halides to ynamides under mild conditions. The products α-haloenamides were further transformed into multisubstituted enamides via Suzuki and Sonogashira cross-coupling reactions.

Publication types

  • Research Support, Non-U.S. Gov't