Immunoprint pattern in patients with allergic bronchopulmonary aspergillosis in different stages

J Allergy Clin Immunol. 1989 Apr;83(4):839-44. doi: 10.1016/0091-6749(89)90023-7.

Abstract

Individual immunoprint patterns of sodium dodecylsulfate-polyacrylamide gel electrophoresis-separated Aspergillus fumigatus (Af) allergens/antigens were evaluated in 28 patients with allergic bronchopulmonary aspergillosis in stages II to V. It could be demonstrated that active disease (stage III) is characterized by a very strong IgE response against a variety of Af components, whereas the IgE antibody pattern in corticosteroid-treated patients who have demonstrated improvement is much weaker. In patients in remission (stage II), it is minimal. In contrast, many patients in stage V without corticosteroid treatment demonstrated a strong reactivity of IgE antibodies, indicating persisting active disease. The pattern of IgG antibodies with individual Af components resembles, in general, that of IgE antibodies; however, discrimination between different stages and between treated patients is much weaker. Our results indicate that a certain relationship between the different stages of allergic bronchopulmonary aspergillosis and Af immunoprint patterns exists.

MeSH terms

  • Allergens / isolation & purification*
  • Antibodies, Fungal / isolation & purification*
  • Aspergillosis, Allergic Bronchopulmonary / immunology*
  • Aspergillus fumigatus / immunology*
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Immunoblotting
  • Immunoglobulin E / analysis
  • Radioallergosorbent Test

Substances

  • Allergens
  • Antibodies, Fungal
  • Immunoglobulin E