Abstract
The aqueous extract of the leaves of Ageratina cylindrica afforded six new ent-kaurenoic acid glycosides together with the known diterpenoid paniculoside V, the flavonoid astragalin, chlorogenic acid, and L-chiro-inositol. The structures were elucidated mainly by NMR and MS methods, and the absolute configuration was established by vibrational circular dichroism spectroscopy. The new compounds showed moderate antiprotozoal activity against Entamoeba histolytica and Giardia lamblia trophozoites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ageratina / chemistry*
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Animals
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification*
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Antiprotozoal Agents / pharmacology
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Circular Dichroism
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Diterpenes
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / isolation & purification*
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Diterpenes, Kaurane / pharmacology
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Entamoeba histolytica / drug effects
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Giardia lamblia / drug effects
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Kaempferols / chemistry
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Kaempferols / isolation & purification
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Parasitic Sensitivity Tests
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Plant Leaves / drug effects
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Trophozoites / drug effects
Substances
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Antiprotozoal Agents
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Diterpenes
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Diterpenes, Kaurane
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Glycosides
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Kaempferols
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kaurene
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kaurenoic acid
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astragalin