Crosstalk between stem cell and cell cycle machineries

Michael S Kareta; Julien Sage; Marius Wernig

doi:10.1016/j.ceb.2015.10.001

Crosstalk between stem cell and cell cycle machineries

Curr Opin Cell Biol. 2015 Dec:37:68-74. doi: 10.1016/j.ceb.2015.10.001. Epub 2015 Nov 11.

Authors

Michael S Kareta¹, Julien Sage², Marius Wernig³

Affiliations

¹ Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
² Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: [email protected].
³ Department of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: [email protected].

Abstract

Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Cycle*
Cell Differentiation / physiology
Cellular Reprogramming
Embryonic Stem Cells / cytology*
Humans
Pluripotent Stem Cells / cytology*

Grants and funding

R01 CA114102/CA/NCI NIH HHS/United States