Psychiatric and neuropsychological issues in Marfan syndrome: A critical review of the literature

Int J Psychiatry Med. 2015;50(4):347-60. doi: 10.1177/0091217415612701. Epub 2015 Nov 2.

Abstract

The cooccurrence of Marfan syndrome and psychiatric disorders has been reported for many years. Furthermore, neuropsychological deficits have been shown to be associated with Marfan syndrome. The aim of the present article is to summarize findings from the sparse studies and case reports available. The results hold clinical and therapeutic implications and suggest that psychological and neuropsychological domains in Marfan syndrome patients should be carefully assessed. In particular, some patients may require specific rehabilitation programs. On this basis, a multidisciplinary approach to Marfan syndrome treatment seems mandatory.

Keywords: Marfan; psychiatry; review.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / genetics
  • Cognition Disorders / psychology*
  • Cognition Disorders / therapy
  • Cooperative Behavior
  • Female
  • Fibrillins
  • Humans
  • Interdisciplinary Communication
  • Male
  • Marfan Syndrome / diagnosis*
  • Marfan Syndrome / genetics
  • Marfan Syndrome / psychology*
  • Marfan Syndrome / therapy
  • Mental Disorders / diagnosis*
  • Mental Disorders / genetics
  • Mental Disorders / psychology*
  • Mental Disorders / therapy
  • Microfilament Proteins / genetics
  • Mutation
  • Neurocognitive Disorders / diagnosis*
  • Neurocognitive Disorders / genetics
  • Neurocognitive Disorders / psychology*
  • Neurocognitive Disorders / therapy
  • Neuropsychological Tests
  • Young Adult

Substances

  • Fibrillins
  • Microfilament Proteins