Successes and Challenges of PARP Inhibitors in Cancer Therapy

Front Oncol. 2015 Oct 14:5:222. doi: 10.3389/fonc.2015.00222. eCollection 2015.

Authors

Tiffany K Ricks¹, Haw-Jyh Chiu¹, Gwynn Ison¹, Geoffrey Kim¹, Amy E McKee¹, Paul Kluetz¹, Richard Pazdur¹

Affiliation

¹ Office of Hematology and Oncology Products (OHOP), Office of New Drugs (OND), Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration , Silver Spring, MD , USA.

No abstract available

Keywords: BRCA1; BRCA2; PARP inhibitor; cancer; drug resistance; homologous recombination.

Publication types

Review