Oncogenic PI3Kα promotes multipotency in breast epithelial cells

Sci Signal. 2015 Nov 3;8(401):pe3. doi: 10.1126/scisignal.aad5856.

Abstract

The phosphoinositide 3-kinase (PI3K) signaling pathway is among the most frequently altered in cancer. Now, two studies show that a mutated oncogenic PI3Kα, commonly found in breast cancer, leads to dedifferentiation or destabilization of luminal and basal epithelial lineages, which in turn leads to increased cancer cell heterogeneity.

Publication types

  • Review

MeSH terms

  • Breast / enzymology*
  • Breast / pathology
  • Breast Neoplasms* / enzymology
  • Breast Neoplasms* / genetics
  • Epithelial Cells / enzymology*
  • Epithelial Cells / pathology
  • Female
  • Humans
  • Multipotent Stem Cells / enzymology*
  • Multipotent Stem Cells / pathology
  • Mutation
  • Neoplasm Proteins* / genetics
  • Neoplasm Proteins* / metabolism
  • Neoplastic Stem Cells* / enzymology
  • Neoplastic Stem Cells* / pathology
  • Phosphatidylinositol 3-Kinases* / genetics
  • Phosphatidylinositol 3-Kinases* / metabolism

Substances

  • Neoplasm Proteins
  • Phosphatidylinositol 3-Kinases