Abstract
The phosphoinositide 3-kinase (PI3K) signaling pathway is among the most frequently altered in cancer. Now, two studies show that a mutated oncogenic PI3Kα, commonly found in breast cancer, leads to dedifferentiation or destabilization of luminal and basal epithelial lineages, which in turn leads to increased cancer cell heterogeneity.
Copyright © 2015, American Association for the Advancement of Science.
MeSH terms
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Breast / enzymology*
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Breast / pathology
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Breast Neoplasms* / enzymology
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Breast Neoplasms* / genetics
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Epithelial Cells / enzymology*
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Epithelial Cells / pathology
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Female
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Humans
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Multipotent Stem Cells / enzymology*
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Multipotent Stem Cells / pathology
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Mutation
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Neoplasm Proteins* / genetics
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Neoplasm Proteins* / metabolism
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Neoplastic Stem Cells* / enzymology
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Neoplastic Stem Cells* / pathology
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Phosphatidylinositol 3-Kinases* / genetics
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Phosphatidylinositol 3-Kinases* / metabolism
Substances
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Neoplasm Proteins
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Phosphatidylinositol 3-Kinases