Abstract
Cancer cachexia leads to involuntary weight loss resulting from the atrophy of skeletal muscle and adipose tissues. Now, in metastatic mouse models of cancer, investigators reveal a cross talk pathway between bone and muscle that provides a new understanding of wasting in advanced cancers.
MeSH terms
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Animals
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Bone Neoplasms / complications
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Bone Neoplasms / metabolism*
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Bone Neoplasms / secondary
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Bone Resorption / etiology
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Bone Resorption / metabolism
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Cachexia / etiology
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Cachexia / metabolism*
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Calcium / metabolism
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Humans
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Mice
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Muscle Weakness / etiology
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Muscle Weakness / metabolism
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Muscle, Skeletal / metabolism*
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NADPH Oxidases / metabolism
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Neoplasms / complications
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Neoplasms / metabolism*
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Ryanodine Receptor Calcium Release Channel / metabolism
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Sarcoplasmic Reticulum / metabolism
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Signal Transduction
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Smad3 Protein / metabolism
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Transforming Growth Factor beta / metabolism*
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Troponin / metabolism
Substances
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Ryanodine Receptor Calcium Release Channel
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Smad3 Protein
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Transforming Growth Factor beta
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Troponin
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NADPH Oxidases
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Calcium