Fragile Nucleosomes Influence Pol II Promoter Function

Suman K Pradhan; Yong Xue; Michael F Carey

doi:10.1016/j.molcel.2015.10.035

Fragile Nucleosomes Influence Pol II Promoter Function

Mol Cell. 2015 Nov 5;60(3):342-3. doi: 10.1016/j.molcel.2015.10.035.

Authors

Suman K Pradhan¹, Yong Xue¹, Michael F Carey²

Affiliations

¹ Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
² Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: [email protected].

PMID: 26545072
DOI: 10.1016/j.molcel.2015.10.035

Abstract

In this issue of Molecular Cell, Kubik et al. (2015) describe how the RSC chromatin remodeling complex collaborates with two DNA sequence motifs and sequence-specific general regulatory factors to assemble fragile nucleosomes at highly transcribed yeast Pol II promoters, and they distinguish these from promoters bearing stable nucleosomes.

Publication types

Comment

MeSH terms

Gene Expression Regulation, Fungal / physiology*
Nucleosomes / metabolism*
Promoter Regions, Genetic / physiology*
Saccharomyces cerevisiae / metabolism*
Saccharomyces cerevisiae Proteins / biosynthesis*

Substances

Nucleosomes
Saccharomyces cerevisiae Proteins