Higher Rates of Retinopathy of Prematurity after Increasing Oxygen Saturation Targets for Very Preterm Infants: Experience in a Single Center

Brett J Manley; Carl A Kuschel; James E Elder; Lex W Doyle; Peter G Davis

doi:10.1016/j.jpeds.2015.10.005

Higher Rates of Retinopathy of Prematurity after Increasing Oxygen Saturation Targets for Very Preterm Infants: Experience in a Single Center

J Pediatr. 2016 Jan:168:242-244. doi: 10.1016/j.jpeds.2015.10.005. Epub 2015 Nov 6.

Authors

Brett J Manley¹, Carl A Kuschel², James E Elder³, Lex W Doyle⁴, Peter G Davis⁴

Affiliations

¹ The Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics and Gynecology, Melbourne, Australia. Electronic address: [email protected].
² The Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics and Gynecology, Melbourne, Australia.
³ The Royal Women's Hospital, Melbourne, Australia; Department of Pediatrics, The University of Melbourne, Melbourne, Australia; The Royal Children's Hospital, Melbourne, Australia.
⁴ The Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics and Gynecology, Melbourne, Australia; Murdoch Children's Research Center, Melbourne, Australia.

PMID: 26548746
DOI: 10.1016/j.jpeds.2015.10.005

Abstract

Randomized trials of oxygen saturation target ranges for extremely preterm infants showed increased survival but increased retinopathy of prematurity with higher compared with lower target ranges. In our center, changing from a target range of 88%-92% to 91%-95% has been associated with increased rates and severity of retinopathy of prematurity.

MeSH terms

Female
Humans
Infant, Newborn
Infant, Premature
Male
Oxygen / administration & dosage*
Oxygen / metabolism
Retinopathy of Prematurity / chemically induced*
Retinopathy of Prematurity / epidemiology*
Retrospective Studies

Substances

Oxygen