Role of extracellular vesicles in autoimmune diseases

Delphine Turpin; Marie-Elise Truchetet; Benjamin Faustin; Jean-François Augusto; Cécile Contin-Bordes; Alain Brisson; Patrick Blanco; Pierre Duffau

doi:10.1016/j.autrev.2015.11.004

Role of extracellular vesicles in autoimmune diseases

Autoimmun Rev. 2016 Feb;15(2):174-83. doi: 10.1016/j.autrev.2015.11.004. Epub 2015 Nov 7.

Authors

Delphine Turpin¹, Marie-Elise Truchetet², Benjamin Faustin³, Jean-François Augusto⁴, Cécile Contin-Bordes⁵, Alain Brisson⁶, Patrick Blanco⁷, Pierre Duffau⁸

Affiliations

¹ Immunology and Immunogenetic Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France. Electronic address: [email protected].
² Rheumatology Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France; UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: [email protected].
³ UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: [email protected].
⁴ UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: [email protected].
⁵ Immunology and Immunogenetic Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France; UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: [email protected].
⁶ UMR-5248-CBMN CNRS University of Bordeaux-IBP, allée Geoffroy Saint-Hilaire, 33600 Pessac, France. Electronic address: [email protected].
⁷ Immunology and Immunogenetic Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France; UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: [email protected].
⁸ UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France; Internal Medicine and Clinical Immunology Department, Bordeaux Hospital, 1 rue Jean Burguet, 33075 Bordeaux Cedex, France. Electronic address: [email protected].

PMID: 26554931
DOI: 10.1016/j.autrev.2015.11.004

Abstract

Extracellular vesicles (EVs) consist of exosomes released upon fusion of multivesicular bodies with the cell plasma membrane and microparticles shed directly from the cell membrane of many cell types. EVs can mediate cell-cell communication and are involved in many processes including inflammation, immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. Accumulating evidence reveals that EVs act in the establishment, maintenance and modulation of autoimmune processes among several others involved in cancer and cardiovascular complications. EVs could also present biomedical applications, as disease biomarkers and therapeutic targets or agents for drug delivery.

Keywords: Autoimmune diseases; Exosomes; Extracellular vesicles; Microparticles; Rheumatoid arthritis; Systemic lupus erythematosus.

Publication types

Review

MeSH terms

Autoimmune Diseases / immunology*
Autoimmune Diseases / metabolism
Biological Transport
Cell Communication
Extracellular Vesicles / immunology*
Extracellular Vesicles / metabolism
Humans
Signal Transduction