Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Muhammad Shoaib; Claus Storgaard Sørensen

doi:10.1016/j.ccell.2015.10.009

Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Cancer Cell. 2015 Nov 9;28(5):545-547. doi: 10.1016/j.ccell.2015.10.009.

Authors

Muhammad Shoaib¹, Claus Storgaard Sørensen²

Affiliations

¹ Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.
² Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark. Electronic address: [email protected].

PMID: 26555168
DOI: 10.1016/j.ccell.2015.10.009

Abstract

Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.

Publication types

Comment

MeSH terms

Animals
Cell Cycle Proteins / metabolism*
Histones / metabolism*
Humans
Neoplasms / metabolism*
Nuclear Proteins / metabolism*
Nucleotides / metabolism*
Protein-Tyrosine Kinases / metabolism*

Substances

Cell Cycle Proteins
Histones
Nuclear Proteins
Nucleotides
Protein-Tyrosine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding