Objective: To investigate the distribution of HCV genotypes in Chinese Han population with chronic hepatitis C (CHC).
Methods: This randomized multicenter study included 1 014 CHC patients from 28 hospitals in different regions of China. SPSS 20.0 was applied to analyze the relationship among region, HCV genotype, gender and the replication level of HCV-RNA.
Results: HCV 1 genotype (56.80%) was the most common genotype. The majority of CHC patients were of genotype 1, 2, 3, 6 in the order of frequency, except those in southwestern, southern and central China. HCV 1, 2, 3, 6 genotypes were most common among male patients in southern China; among female patients in northern China; among male patients in northern and northwestern China and among male patients in northwestern China, respectively (all P <0.05). There was no statistical significance between different genders in other regions. The high viral load was more common than the low viral load among HCV 1, 2, 3, 6 genotype-infected patients.
Conclusion: There are different distributions of HCV genotypes among the different regions. In addition, HCV genotypes are correlated with gender and HCV-RNA load.
目的: 调查中国大陆汉族慢性丙型肝炎(CHC)患者的HCV基因型与地区分布、性别、HCV-RNA复制水平之间的关系.
方法: 选取来自中国大陆不同地区28家医院的1 014例汉族CHC患者, 对其性别、分布区域、HCV基因型、HCV-RNA复制水平等指标进行调查, 用SPSS 20.0软件进行数据处理, 采用 χ 2检验分析各指标的相互关系.
结果: ① 中国大陆HCV 1型患者人数最多(56.80%); 除西南、华南、华中地区外, 其余地区HCV基因型分布频度均为HCV 1型>HCV 2型>HCV 3型>HCV 6型.② HCV 1型在华南地区男性患者多见( P < 0.05);HCV 2型在华北地区女性多见( P < 0.05);HCV 3型在华北、西北地区男性多见( P < 0.05);HCV 6型在西北地区男性多见( P < 0.05), 其余各地区不同性别间HCV基因型分布差异无统计学意义.③ 在HCV 1、HCV 2、HCV 3、HCV 6型中, 均多见HCV-RNA高水平复制, 低水平复制患者数最少.
结论: 中国大陆汉族CHC患者HCV基因型在各地区分布不同, 并与性别、HCV-RNA复制水平有关.