Small molecule screen identifies differentiation-promoting compounds targeting genetically diverse acute myeloid leukaemia

Br J Haematol. 2016 Oct;175(2):342-346. doi: 10.1111/bjh.13851. Epub 2015 Nov 16.
No abstract available

Keywords: acute myeloid leukaemia-initiating cells; differentiation; small molecule screen.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation / drug effects*
  • Cell Line, Tumor
  • Coculture Techniques
  • Early Detection of Cancer / methods*
  • Genetic Variation
  • Humans
  • Indoles / therapeutic use
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / genetics*
  • Small Molecule Libraries / therapeutic use*

Substances

  • Indoles
  • Small Molecule Libraries
  • indirubin